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. 2022 Apr 29;13:913778. doi: 10.3389/fphar.2022.913778

FIGURE 2.

FIGURE 2

Neferine preserved cardiac function and improved the survival rate in LPS-treated mice. (A) Neferine (20 mg/kg) was intraperitoneally administered 2 h before LPS injection (15 mg/kg) and then administered for three consecutive days. The mortality of mice within 72 h was recorded (n = 15 mice). (B–I) the mice were treated with neferine (20 mg/kg, intraperitoneally (i.p.) 2 h before LPS challenge (10 mg/kg, i.p.), and cardiac function was examined (n = 6). (B) Representative echocardiographic images. (C) Heart rate (HR). (D) Fractional shortening (FS). (E) Ejection fraction (EF). (F) Left ventricular internal systolic dimension (LVIDs). (G) Left ventricular internal diastolic dimension (LVIDd). (H) Left ventricular posterior wall systolic thickness (LVPWs). (I) Left ventricular posterior wall diastolic thickness (LVPWd). Data are expressed as mean ± standard deviation. *p < 0.05, **p < 0.01, ***p < 0.001; ns: no significant difference.