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. 2022 Apr 29;13:913778. doi: 10.3389/fphar.2022.913778

FIGURE 6.

FIGURE 6

Neferine reversed the LPS-induced downregulation of the PI3K/AKT/mTOR signaling pathway in vivo and in vitro. (A) Representative Western blot images of p-PI3K, PI3K, p-AKT, AKT, p-mTOR, and mTOR in mice. (B–E) Representative Western blot images of p-PI3K, PI3K, p-AKT, AKT, p-mTOR, and mTOR in H9c2 cells. (C) Densitometric quantification analysis of the protein expression levels of p-PI3K, PI3K, p-AKT, AKT, p-mTOR, and mTOR in mice. (D–F) Densitometric quantification analysis of the protein expression levels of p-PI3K, PI3K, p-AKT, AKT, p-mTOR, and mTOR in H9c2 cells. All data are expressed as mean ± standard deviation. All experiments were repeated at least three times. *p < 0.05, **p < 0.01, ***p < 0.001; ns: no significant difference.