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. 2022 Apr 29;13:874769. doi: 10.3389/fimmu.2022.874769

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Copyright © 2022 Aubin, Lombard-Vadnais, Collin, Aliesky, McLachlan and Lesage

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The NOD.H2^h4 congenic mouse model. Representation of the mouse chromosome 17 from the parental B10.A(4R) (left), parental NOD (middle), and congenic NOD.H2^h4 (right) strains. By backcrossing NOD mice to B10.A(4R), the thyroiditis-prone H2^h4 MHC locus from chromosome 17 of the parental B10.A(4R) mouse has been selected at each backcross generation to replace in the NOD-derived H2^g7 MHC locus, resulting in the NOD.H2^h4 congenic mouse.