Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 29;13:874769. doi: 10.3389/fimmu.2022.874769

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Aubin, Lombard-Vadnais, Collin, Aliesky, McLachlan and Lesage

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Disruption of T cell activation signals induce autoimmune neuropathy in the NOD mouse. Autoimmune neuropathy can be induced in the NOD mouse after modulation of one of the three T cell activation signals. More specifically, mutations in AIRE transcription factor expression in medullary thymic epithelial cells (mTECs) indirectly impact signal 1. In addition, disruptions in co-stimulation signals, such as ICOS/ICOSL and CD28/CD80-86 (signal 2), or neutralization of IL-2 (signal 3) induce autoimmune neuropathy in the NOD mouse.