FIGURE 1.

Schematic representation of key developmental differences between neonatal and adult platelets, and potential effects on immune cells. Upon activation, human neonatal platelets express less P‐selectin and release their alpha granule content (including cytokines and chemokines) less effectively than adult platelets. Decreased P‐selectin surface expression results in a reduced ability to interact with and activate immune cells, including neutrophils and monocytes. A neutrophil is shown as an example. The reduced NET formation in neonates is due to the presence of a placenta‐derived NET inhibitor. Abbreviations: NET, neutrophil extracellular trap; PSGL‐1, P‐selectin glycoprotein ligand‐1