TABLE 1.
Key differences in neonatal platelet function, primary hemostasis, and compensatory factors in neonatal blood, compared to adults
|
Platelet function (in neonates vs adults) |
Primary hemostasis (in neonates vs adults) |
Compensatory factors (in neonates vs adults) |
|---|---|---|
| ↓↓ response to epinephrine | Shorter bleeding times | ↑ concentration of VWF |
| ↓ response to thrombin/TRAP | Shorter closure times (PFA‐100) b | ↑ proportion of VWF ultra‐large multimers |
| ↓ response to ADP | ↑ hematocrit | |
| ↓ response to thromboxane | ↑ mean corpuscular volume | |
| ↓↓ response to collagen | ||
| ↓↓ response to rhodocytin a | ||
| ↓ degranulation | ||
| ↑ sensitivity to inhibition by PGE1 |
Abbreviations: PFA‐100: Platelet Function Analyzer‐100; PGE1, prostaglandin E1; TRAP, thrombin receptor activating peptide; VWF, von Willebrand factor.
a
CLEC‐2 ligand.
b
Closure times in response to collagen/epinephrine and collagen/ADP.