TABLE 2.
GO and KEGG pathway enrichment analysis of DEGs in PDA samples
| Category | Term | Count | p‐Value |
|---|---|---|---|
| GOTERM_BP_DIRECT | GO:0007155~cell adhesion | 19 | 3.61E−06 |
| GOTERM_BP_DIRECT | GO:0030574~collagen catabolic process | 8 | 6.66E−06 |
| GOTERM_BP_DIRECT | GO:0050900~leukocyte migration | 9 | 6.40E−05 |
| GOTERM_BP_DIRECT | GO:0030199~collagen fibril organization | 6 | 6.70E−05 |
| GOTERM_BP_DIRECT | GO:0035987~endodermal cell differentiation | 5 | 2.10E−04 |
| GOTERM_BP_DIRECT | GO:0030277~maintenance of gastrointestinal epithelium | 4 | 2.73E−04 |
| GOTERM_BP_DIRECT | GO:0030198~extracellular matrix organization | 10 | 3.42E−04 |
| GOTERM_BP_DIRECT | GO:0010906~regulation of glucose metabolic process | 4 | 0.001763481 |
| GOTERM_BP_DIRECT | GO:0045893~positive regulation of transcription, DNA‐templated | 15 | 0.001824127 |
| GOTERM_BP_DIRECT | GO:0042060~wound healing | 6 | 0.001941507 |
| GOTERM_BP_DIRECT | GO:0008284~positive regulation of cell proliferation | 14 | 0.002110314 |
| GOTERM_BP_DIRECT | GO:0090090~negative regulation of canonical Wnt signaling pathway | 8 | 0.00228459 |
| GOTERM_BP_DIRECT | GO:0010628~positive regulation of gene expression | 10 | 0.00262849 |
| GOTERM_BP_DIRECT | GO:0042475~odontogenesis of dentin‐containing tooth | 5 | 0.003200207 |
| GOTERM_BP_DIRECT | GO:0006508~proteolysis | 14 | 0.003853736 |
| GOTERM_BP_DIRECT | GO:0071407~cellular response to organic cyclic compound | 5 | 0.00412687 |
| GOTERM_BP_DIRECT | GO:0043586~tongue development | 3 | 0.005179886 |
| GOTERM_BP_DIRECT | GO:1902042~negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 4 | 0.005714744 |
| GOTERM_BP_DIRECT | GO:0001649~osteoblast differentiation | 6 | 0.006006712 |
| GOTERM_BP_DIRECT | GO:0050919~negative chemotaxis | 4 | 0.006217342 |
| GOTERM_BP_DIRECT | GO:0097192~extrinsic apoptotic signaling pathway in absence of ligand | 4 | 0.006217342 |
| GOTERM_BP_DIRECT | GO:0060394~negative regulation of pathway‐restricted SMAD protein phosphorylation | 3 | 0.007487389 |
| GOTERM_CC_DIRECT | GO:0005615~extracellular space | 35 | 1.41E−06 |
| GOTERM_CC_DIRECT | GO:0005576~extracellular region | 39 | 1.56E−06 |
| GOTERM_CC_DIRECT | GO:0031012~extracellular matrix | 15 | 3.04E−06 |
| GOTERM_CC_DIRECT | GO:0005578~proteinaceous extracellular matrix | 14 | 5.22E−06 |
| GOTERM_CC_DIRECT | GO:0070062~extracellular exosome | 52 | 3.99E−05 |
| GOTERM_CC_DIRECT | GO:0005581~collagen trimer | 8 | 5.14E−05 |
| GOTERM_CC_DIRECT | GO:0009897~external side of plasma membrane | 9 | 0.001863917 |
| GOTERM_CC_DIRECT | GO:0045121~membrane raft | 8 | 0.006117264 |
| GOTERM_MF_DIRECT | GO:0005509~calcium ion binding | 22 | 5.53E−05 |
| GOTERM_MF_DIRECT | GO:0001968~fibronectin binding | 4 | 0.002970899 |
| GOTERM_MF_DIRECT | GO:0000900~translation repressor activity, nucleic acid binding | 3 | 0.005289145 |
| GOTERM_MF_DIRECT | GO:0005178~integrin binding | 6 | 0.006536482 |
| GOTERM_MF_DIRECT | GO:0031994~insulin‐like growth factor I binding | 3 | 0.007644107 |
| GOTERM_MF_DIRECT | GO:0004252~serine‐type endopeptidase activity | 9 | 0.008138653 |
| KEGG_PATHWAY | hsa05200:Pathways in cancer | 15 | 1.11E−04 |
| KEGG_PATHWAY | hsa04512:ECM‐receptor interaction | 7 | 4.26E−04 |
| KEGG_PATHWAY | hsa04974:Protein digestion and absorption | 7 | 4.53E−04 |
| KEGG_PATHWAY | hsa04668:TNF signaling pathway | 6 | 0.007120596 |
| KEGG_PATHWAY | hsa04510:Focal adhesion | 8 | 0.008530044 |
Abbreviations: DEGs, differentially expressed genes; GO, gene ontology; KEGG, kyoto encyclopedia of genes and genomes; PDA, pancreatic ductal adenocarcinoma.