1 |
CDK1 |
Cyclin‐dependent kinase 1 |
CDK1 is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle, and associated with breast cancer |
32 |
2 |
ASPM |
Assembly factor for spindle microtubules |
ASPM is essential for normal mitotic spindle function in embryonic neuroblasts, poor prognosis, and regulates cell proliferation in bladder cancer |
28 |
3 |
KIF11 |
Kinesin family member 11 |
KIF11 encodes a motor protein, and associated with colorectal cancer |
28 |
4 |
HMMR |
Hyaluronan‐mediated motility receptor |
HMMR is involved in cell motility, potentially associated with higher risk of breast cancer |
24 |
5 |
CEP55 |
Centrosomal protein 55 |
Plays a role in mitotic exit and cytokinesis, may regulate breast cancer spinal metastases |
24 |
6 |
UHRF1 |
Ubiquitin like with PHD and ring finger domains 1 |
UHRF1 plays a major role in the G1/S transition and retinoblastoma gene expression, and is up‐regulated in various cancers |
24 |
7 |
DLGAP5 |
DLG‐associated protein 5 |
DLGAP5 is a potential cell cycle regulator, and overexpressed in hepatocellular carcinoma |
24 |
8 |
PBK |
PDZ‐binding kinase |
PBK overexpression in tumorigenesis, and drives androgen‐independent growth in prostate cancer |
24 |
9 |
RAD51AP1 |
RAD51‐associated protein 1 |
Structure‐specific DNA‐binding protein involved in DNA repair, and promotes progression of ovarian cancer |
22 |
10 |
SHCBP1 |
SHC binding and spindle‐associated 1 |
SHCBP1 promotes the progression of prostate cancer |
20 |
11 |
DTL |
Denticleless E3 ubiquitin protein ligase homolog |
DTL is involved in cell cycle control, and associated with endometrial squamous cell carcinoma |
20 |
12 |
HMGB2 |
High mobility group box 2 |
HMGB2 may promote proliferation and invasion of renal tumor |
16 |