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. 2022 Apr 11;36(5):e24381. doi: 10.1002/jcla.24381

TABLE 3.

Functional roles of 12 hub genes with degree ≥5

No. Gene symbol Full name Function Degree
1 CDK1 Cyclin‐dependent kinase 1 CDK1 is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle, and associated with breast cancer 32
2 ASPM Assembly factor for spindle microtubules ASPM is essential for normal mitotic spindle function in embryonic neuroblasts, poor prognosis, and regulates cell proliferation in bladder cancer 28
3 KIF11 Kinesin family member 11 KIF11 encodes a motor protein, and associated with colorectal cancer 28
4 HMMR Hyaluronan‐mediated motility receptor HMMR is involved in cell motility, potentially associated with higher risk of breast cancer 24
5 CEP55 Centrosomal protein 55 Plays a role in mitotic exit and cytokinesis, may regulate breast cancer spinal metastases 24
6 UHRF1 Ubiquitin like with PHD and ring finger domains 1 UHRF1 plays a major role in the G1/S transition and retinoblastoma gene expression, and is up‐regulated in various cancers 24
7 DLGAP5 DLG‐associated protein 5 DLGAP5 is a potential cell cycle regulator, and overexpressed in hepatocellular carcinoma 24
8 PBK PDZ‐binding kinase PBK overexpression in tumorigenesis, and drives androgen‐independent growth in prostate cancer 24
9 RAD51AP1 RAD51‐associated protein 1 Structure‐specific DNA‐binding protein involved in DNA repair, and promotes progression of ovarian cancer 22
10 SHCBP1 SHC binding and spindle‐associated 1 SHCBP1 promotes the progression of prostate cancer 20
11 DTL Denticleless E3 ubiquitin protein ligase homolog DTL is involved in cell cycle control, and associated with endometrial squamous cell carcinoma 20
12 HMGB2 High mobility group box 2 HMGB2 may promote proliferation and invasion of renal tumor 16