TABLE 3.

Functional roles of 12 hub genes with degree ≥5

No.	Gene symbol	Full name	Function	Degree
1	CDK1	Cyclin‐dependent kinase 1	CDK1 is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle, and associated with breast cancer	32
2	ASPM	Assembly factor for spindle microtubules	ASPM is essential for normal mitotic spindle function in embryonic neuroblasts, poor prognosis, and regulates cell proliferation in bladder cancer	28
3	KIF11	Kinesin family member 11	KIF11 encodes a motor protein, and associated with colorectal cancer	28
4	HMMR	Hyaluronan‐mediated motility receptor	HMMR is involved in cell motility, potentially associated with higher risk of breast cancer	24
5	CEP55	Centrosomal protein 55	Plays a role in mitotic exit and cytokinesis, may regulate breast cancer spinal metastases	24
6	UHRF1	Ubiquitin like with PHD and ring finger domains 1	UHRF1 plays a major role in the G1/S transition and retinoblastoma gene expression, and is up‐regulated in various cancers	24
7	DLGAP5	DLG‐associated protein 5	DLGAP5 is a potential cell cycle regulator, and overexpressed in hepatocellular carcinoma	24
8	PBK	PDZ‐binding kinase	PBK overexpression in tumorigenesis, and drives androgen‐independent growth in prostate cancer	24
9	RAD51AP1	RAD51‐associated protein 1	Structure‐specific DNA‐binding protein involved in DNA repair, and promotes progression of ovarian cancer	22
10	SHCBP1	SHC binding and spindle‐associated 1	SHCBP1 promotes the progression of prostate cancer	20
11	DTL	Denticleless E3 ubiquitin protein ligase homolog	DTL is involved in cell cycle control, and associated with endometrial squamous cell carcinoma	20
12	HMGB2	High mobility group box 2	HMGB2 may promote proliferation and invasion of renal tumor	16