TABLE 1.

Characteristics of the case series studies

First author	Country	Published time	No. of patients	Median age (years)	Male/female	Encephalitis diagnosis method	CT results	MRI results	Special encephalitis treatment	SARS‐CoV‐2 diagnosis method	COVID‐19 treatment	Clinical manifestations	SARS‐CoV‐2 diagnosis in CSF sample	Comorbidities	Outcomes
Lopes CCB 32	Brazil	December 2020	2	50	1M, 1F	2 brain CT scan, 2 brain MRI, 2 EEG	2 bilateral lesions in the centrum semiovale/1 focal lesions in globus pallidus and internal capsule/1 signal abnormalities in the white matter, including corpus callosum	2 multifocal hyperintensity in centrum semiovale, 1 lesions in the cerebellar white matter and globus pallidus	NM	2 RT‐PCR	1 hydroxychloroquine	2 fever, 2 RS, 1 renal failure, 2 delayed awakening after sedation withdrawal, 2 DC, 1 coma, 1 four‐limb weakness	2 negative	2 hypertension, 1 diabetes, 1 obesity, 1 smoking	1 death, 1 partial recovery
Kihira S 33	USA	October 2020	5	48.6	3M, 2F	MRI, head CT, EEG	5 unremarkable	5 hyperintensity in the white matter, 3 confluent diffusion restriction in the cerebral white matter, 2 hyperintensity in the splenium of corpus callosum/1 scattered frontoparietal hyperintensity/1 microhemorrhages in corpus callosum/1 intraventricular hemorrhage	1 plasma exchange	5 RT‐PCR	NM	1 myocardial infarction, 2 fever, 5 RS, 3 acute renal failure, 1 cardiogenic shock, 1 abdominal pain, 1 cardiac arrest, 1 nausea, 1 vomiting, 1 chills, 5 AMS, 1 focal seizures, 1 lower limbs paralysis	3 negative, 1 NP, 1 NM	1 Hypertension, 1 diabetes mellitus type 2, 1 pyelonephritis, 1 gestation, 1 obesity	NM
Barreto‐Acevedo E 34	Peru	June, 2020	2	50.5	1M, 1F	MRI, CSF analysis, brain tomography	2 unremarkable	1unremarkable, 1 NP	Dexamethasone	RT‐PCR, serological test	NM	2 fever, 2 chills, 1 malaise, 1 headache, 2 AMS, 2 seizures	NP	1 obesity	1death, 1 transferred to other hospital
Delorme C 35	France	August 2020	4	66.75	2M, 2F	Brain MRI, CSF analysis, brain FDG‐PET/CT imaging, EEG	4 NP	1 unremarkable/1 non‐specific Hyperintensity of the white matter/1 right T2 orbitofrontal Hyperintensity	3 IV immunoglobulin, 3 IV corticosteroids	4 RT‐PCR	NM	4 cognitive impairment, 2 cerebellar syndrome, 1 myoclonus, 1 psychiatric symptoms, 4 fever, 3 RS, 2 anosmia, 1 ageusia, 1 diarrhea, 2 fatigue, 2 agitation, 1 psychomotor slowing, 1 convulsive status, 1 apraxia, 1 dysexecutive syndrome	4 negative	1 temporal lobe epilepsy (hippocampal sclerosis), 1 diabetes mellitus type2, 1 hypertension	4 discharged