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. 2022 May 9;11(9):2672. doi: 10.3390/jcm11092672

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison of defecation frequency before and after 7 days of naldemedine administration. (a) Comparison of the frequency of defecation before and after naldemedine administration in all patients (N = 149). (b) Comparison of defecation frequency before and after naldemedine administration among patients with defecation frequency < 3 times in the week before naldemedine administration (N = 66). * One patient data point is outside the axis limits. (c) Comparison of defecation frequency before and after naldemedine administration among patients who received <30 mg/day of morphine equivalent (N = 60). (d) Comparison of defecation frequency before and after naldemedine administration among patients who received ≥30 mg/day of morphine equivalent (N = 89). ** Three patient data points are outside the axis limits.

Comparison of defecation frequency before and after 7 days of naldemedine administration. (a) Comparison of the frequency of defecation before and after naldemedine administration in all patients (N = 149). (b) Comparison of defecation frequency before and after naldemedine administration among patients with defecation frequency < 3 times in the week before naldemedine administration (N = 66). * One patient data point is outside the axis limits. (c) Comparison of defecation frequency before and after naldemedine administration among patients who received <30 mg/day of morphine equivalent (N = 60). (d) Comparison of defecation frequency before and after naldemedine administration among patients who received ≥30 mg/day of morphine equivalent (N = 89). ** Three patient data points are outside the axis limits.