Figure 5.

Concentration-versus-time profile of a single 0.5 µg/kg dose of dexmedetomidine injected together with levobupivacaine perineurally into the submucosa at the opening of the left (n = 5) or right (n = 5) mandibular foramen in 10 anesthetized dogs. Dogs were premedicated with methadone intravenously, and anesthesia was induced with propofol and maintained with isoflurane in oxygen. Levobupivacaine was used for both infraorbital and inferior alveolar blocks. The data are presented as mean ± SEM.