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. 2022 May 13;20:212. doi: 10.1186/s12967-022-03416-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The GO and pathway enrichment, and protein to protein (PPI) network analysis of VCP-interacting proteins. A The Venn diagram showed 79 VCP-interacting proteins obtained by overlapping the candidates of CoIP/MS and the profile of VCP co-expressed genes in the HCC cohort from TCGA database. B–D The GO enriched terms of top 20 biological processes, cell components, and molecular function, respectively. E, F The enriched pathways through KEGG and Reactome database, separately. G The PPI network of 79 VCP-interacting proteins was analyzed in STRING database and further visualized by Cytoscape software (version 3.8.2). A total of 15 Hub genes were determined by CytoHubba plug-in. The colors of nodes from red to yellow indicated the overall combined scores of each molecule interacting with others from high to low. GO gene ontology, KEGG Kyoto Encyclopedia of Genes and Genomes