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. 2022 May 13;20:104. doi: 10.1186/s12915-022-01315-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — H3K27me3 signatures are shared across functionally distinct human CD34+ hematopoietic progenitor populations. A Schematic of the experimental design and color legend (shown in the bottom right corner) for the 8 cell types analyzed. Unsupervised hierarchical clustering and heatmap of pairwise Spearman correlations for protein coding gene RPKM values (B), H3K4me3 coding gene promoter (± 2 Kb) density (C), and H3K27me3 coding gene promoter density (D) across cell types indicated by color. Genome browser view of H3K27me3 (left panel) and H3K4me3 (right panel) density tracks across cell populations indicated by track color at the CEBPA (E) and GATA1 (F) locus. Unsupervised hierarchical clustering and heatmap showing pairwise Spearman correlation of H3K4me3 (G) and H3K27me3 (H) densities genome-wide