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. 2022 May 13;20:104. doi: 10.1186/s12915-022-01315-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — A majority of active enhancers in mature myeloid cells are marked by H3K27ac in CD34+ progenitor CB cell populations. Unsupervised hierarchical clustering and a heatmap of pairwise Spearman correlations of H3K4me1 (A) and H3K27ac (B) densities across cell types (color legend shown at bottom left). C Number of total enhancers (top panel) and active enhancers (bottom panel) gained or lost in each cell type compared to CD34+CD38− CB cells. Percentage of enhancers (D) and active enhancers (E) in differentiated cells also in CD34+CD38− cells, myeloid progenitor cells, or uniquely in monocytes, erythroblasts, or B or T cells. Expression of genes (left panel) with active enhancers and fractional DNA methylation at active enhancers in erythroblasts (F) and monocytes (G) also in their inferred parental progenitor populations. H Genome browser view of H3K27ac density at SPI1 (top panel) and EPB41 (bottom panel) locus. I Expression (RPKM) of SPI1 (left panel) and EPB4 (right panel) (Wilcoxon test ***p <0.001)