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. 2022 May 6;14(9):1952. doi: 10.3390/nu14091952

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The potential role of the ketogenic diet/nutritional ketosis in neurological disorders. The large amount of ketone bodies formed during a low-carbohydrate, high-fat diet may have a beneficial effect on many of the pathological processes found in neurological diseases, thus potentially offering beneficial adjuvant therapy. (IL-1β: interleukin 1β; IL-6: interleukin 6; TNF-alpha: tumour necrosis factor alpha; HCA-2: hydroxycarboxylic acid 2; NRPL: NOD-like receptor family pyrin domain containing 3 inflammasome; HDAC: histone deacetylases; BDNF: brain-derived neurotrophic factor; GABA: gamma-aminobutyric acid; Aβ: amyloid β).