Table 2.
Information on clinical trials using calorie-restriction-related interventions in human aging studies (summarized in Figure 2B) including study status, interventions and number of participants. Information gathered from www.clinicaltrials.gov, accessed on 17 March 2022.
| Study Title and Phase | Status | Interventions | Enrollment (Estimated) |
|---|---|---|---|
| Calorie Restriction Retards the Aging Process | Unknown | Energy restricted Mediterranean-type diet; 25% calorie restriction | 48 participants |
| The Effect of Food Stimuli on the Calorie Restriction Response in Healthy Subjects | Completed | Stimuli of food smell and vision vs. no stimuli of food smell and vision | 12 participants |
| Effect of Age and Weight Loss on Inflammation and Iron Homeostasis | Completed | Calorie restriction | 44 participants |
| Effect of Resvida, a Comparison with Calorie Restriction Regimen | Completed | Resveratrol, placebo, and calorie restriction | 58 participants |
| Metformin Induces a Dietary Restriction-like State in Human [Phase IV] | Unknown status | Metformin 0.85 twice daily for six months, calorie restriction | 60 participants |
| CALERIE Phase II Ancillary: Metabolic [Phase II] | Completed | Calorie Restriction | 75 participants |
| CALERIE (Tufts)—Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy [Phase I] | Completed | Calorie Restriction | 44 participants |
| Long-term Caloric Restriction and Cellular Aging Markers | Completed—Has results | No interventions | 71 participants |
| CALERIE (Washington University): Comprehensive Assessment of Long-Term Effect of Reducing Intake of Energy [Phase I] | Completed | Calorie Restriction | 48 participants |
| The Effect of Time-restricted Feeding on Physiological Function in Middle-aged and Older Adults [Phase I/II] | Unknown status | Time-restricted feeding | 12 participants |
| CALERIE: Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy | Completed—has results | Calorie restriction and control | 238 participants |
| CALERIE (PBRC, Baton Rouge)—Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy | Completed | Calorie restriction and exercise | 48 participants |