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. 2022 Apr 28;23(9):4887. doi: 10.3390/ijms23094887

Figure 2.

Figure 2

NR prevents HFD-induced neuropathy in C57Bl6 mice (n = 6 to 8 per group). WT C57BL6 mice were randomly assigned to five groups of six to eight mice per group. Group #1: CD; Group # 2: CD + NR 300 mg/kg; Group # 3: HFD; Group # 4: HFD + NR (150 mg/kg); and Group # 5: HFD + NR (300 mg/kg). NR was added to the diet at the dose mentioned to the groups indicated for 2 months. The mice were tested for the following parameters: sciatic motor nerve conduction velocity, SMNCV, (A), tail motor latency, TML, (B), tail sensory nerve conduction velocity, TSNCV, (C), mechanical allodynia by von Frey filament paw withdrawal threshold (D), paw thermal sensitivity by Hargreaves test (E), and IENFD of the hind paw (F). Statistical comparisons were made between the five groups by ANOVA and post hoc Tukey test. *** p < 0.001; HFD, Group # 3 at 2 months compared to all other groups in all parameters.