Table 1.
Metabolic End Points After 2 Months of Treatment in Non-Diabetic (Non-Dia), NMN Treated Non-Diabetic (Non-Dia + NMN), Diabetic (STZ), NMN Treated Diabetic (STZ + NMN) Rats. NS = Not Significant.
| Parameters | WT | Significance | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Non-Dia (n = 6) |
Non-Dia + NMN (100 mg/kg) (n = 6) |
STZ (n = 6) |
STZ + NMN (50 mg/kg) (n = 6) |
STZ + NMN (100 mg /kg) (n = 6) |
1 vs. 2 | 1 vs. 3 | 3 vs. 4 | 3 vs. 5 | |
| Group # | 1 | 2 | 3 | 4 | 5 | ||||
| Body Weight (g) | 450 ± 17 | 431 ± 19 | 346 ± 14 | 345 ± 13 | 331 ± 14 | NS | <0.001 | NS | NS |
| Plasma Glucose (mg/dL) | 132 ± 18 | 128 ± 17 | 405 ± 22 | 399 ± 13 | 388 ± 15 | NS | <0.001 | NS | NS |
| HbA1c% | 5.4 ± 1 | 5.4 ± 1 | 16.7 ± 4.1 | 15.8 ± 2.6 | 15.3 ± 2.9 | NS | <0.01 | NS | NS |
| Insulin (mµ/mL) | 8.3 ± 2 | 8 ± 2 | 1.2 ± 0.7 | 1.3 ± 0.4 | 1.6 ± 0.3 | NS | <0.001 | NS | NS |
| Total Cholesterol (mg/dL) | 68 ± 13 | 59 ± 11 | 173 ± 14 | 133 ± 71 | 139 ± 48 | NS | <0.01 | NS | NS |
| Triglycerides (mg/dL) | 94 ± 11 | 96 ± 9 | 493 ± 23 | 376 ± 22 | 361 ± 19 | NS | <0.001 | <0.05 | <0.05 |
| HDL (mg/dL) | 79 ± 4 | 78 ± 5 | 128 ± 21 | 119 ± 15 | 115 ± 16 | NS | <0.001 | NS | NS |
| LDL (mg/dL) | 13 ± 5 | 10 ± 4 | 63 ± 5 | 64 ± 9 | 60 ± 9 | NS | <0.01 | NS | NS |
| NEFA (mM) | 2.5 ± 0.8 | 3.1 ± 0.4 | 6.6 ± 1.8 | 3.6 ± 1 | 3.8 ± 1 | NS | <0.001 | <0.05 | <0.05 |