Table 2.

Metabolic End Points After 2 Months of Treatment in Non-Diabetic (Non-Dia), Non-Dia + NMN (100 mg/kg intraperitoneal injection on alternate days), Diabetic (STZ), STZ + NMN (50 mg/kg intraperitoneal injection on alternate days) and STZ + NMN (100 mg/kg intraperitoneal injection on alternate days) in C57BL6 Mice. NS = Not Significant.

Parameters	WT					Significance
	Non-Dia (n = 6)	Non-Dia + NMN (100 mg/kg) (n =6)	STZ (n = 6)	STZ + NMN (50 mg/kg) (n = 6)	STZ + NMN (100 mg /kg) (n = 6)	1 vs. 2	1 vs. 3	3 vs. 4	3 vs. 5
Group #	1	2	3	4	5
Body Weight (g)	30 ± 2	31 ± 3	26 ± 4	25 ± 3	21 ± 4	NS	<0.01	NS	NS
Plasma Glucose (mg/dL)	105 ± 12	108 ± 11	405 ± 32	385 ± 33	388 ± 35	NS	<0.001	NS	NS
HbA1c%	5.4 ± 1	5.4 ± 1	15.7 ± 3.1	15.8 ± 3.6	15.3 ± 3.4	NS	<0.001	NS	NS
Insulin (µg/L)	0.8 ± 0.2	0.8 ± 0.2	0.2 ± 0.05	0.18 ± 0.04	0.16 ± 0.03	NS	<0.001	NS	NS
Total Cholesterol (mg/dL)	78 ± 13	75 ± 21	173 ± 42	163 ± 21	169 ± 28	NS	<0.01	NS	NS
Triglycerides (mg/dL)	44 ± 8	36 ± 9	93 ± 13	66 ± 10	61 ± 10	NS	<0.001	<0.05	<0.05
HDL (mg/dL)	79 ± 4	78 ± 5	108 ± 21	99 ± 15	95 ± 16	NS	<0.01	NS	NS
LDL (mg/dL)	43 ± 5	50 ± 4	83 ± 5	84 ± 9	90 ± 9	NS	<0.01	NS	NS
NEFA (mM)	2.5 ± 0.8	3.1 ± 0.4	6.4 ± 1.4	3.6 ± 1	3.6 ± 0.8	NS	<0.001	<0.05	<0.05
Sciatic MNCV (m/s)	55 ± 7	53 ± 6	26 ± 6	42.2 ± 7	46 ± 6.5	NS	<0.001	<0.001	<0.001
Tail MNCV (m/s)	45 ± 4	43 ± 6	24 ± 3	46 ± 4.5	48 ± 5.3	NS	<0.001	<0.001	<0.001
Tail SNCV (m/s)	41 ± 3	43 ± 3	27 ± 5	46 ± 7	48 ± 6	NS	<0.001	<0.001	<0.001
Von Frey Mechanical Allodynia (g)	1.2 ± 0.2	1.3 ± 0.3	0.6 ± 0.1	1.0 ± 0.2	1.2 ± 0.3	NS	<0.001	<0.01	<0.001
Hargreaves Thermal Response (sec)	12 ± 2	14 ± 3	22 ± 4	14 ± 3	12 ± 3	NS	<0.001	<0.001	<0.001
IENFD (# / mm)	25 ± 3	23 ± 4	12 ± 2	23 ± 3	24 ± 3	NS	<0.001	<0.001	<0.001