Table 3.
Metabolic End Points After 2 Months in WT mice Fed With CD, CD + NR (300 mg/kg), HFD, HFD + NR (150 and 300 mg/kg). NS = Not Significant.
| Parameters | WT | Significance | |||||||
|---|---|---|---|---|---|---|---|---|---|
| CD (n = 8) |
CD + NR (300 mg/kg) (n = 8) |
HFD (n = 8) |
HFD + NR (150 mg/kg) (n = 8) |
HFD + NR (300 mg/kg) (n = 8) |
1 vs. 2 | 1 vs. 3 | 3 vs. 4 | 3 vs. 5 | |
| Group # | 1 | 2 | 3 | 4 | 5 | ||||
| Body Weight (g) | 30 ± 2 | 31 ± 3 | 46 ± 4 | 45 ± 3 | 41 ± 4 | NS | <0.001 | NS | NS |
| Plasma Glucose (mg/dL) | 135 ± 18 | 148 ± 17 | 205 ± 22 | 185 ± 13 | 188 ± 15 | NS | <0.001 | NS | NS |
| HbA1c% | 5.4 ± 1 | 5.4 ± 1 | 6.7 ± 1.1 | 5.3 ± 0.6 | 5.8 ± 0.9 | NS | <0.001 | <0.001 | <0.01 |
| Insulin (µg/L) | 0.8 ± 0.2 | 0.8 ± 0.2 | 4 ± 0.5 | 3.8± 0.4 | 3.6 ± 0.3 | NS | <0.001 | NS | NS |
| Total Cholesterol (mg/dL) | 152 ± 32 | 115 ± 12 | 273 ± 42 | 233 ± 51 | 249 ± 21 | NS | <0.001 | <0.05 | <0.05 |
| Triglycerides (mg/dL) | 144 ± 18 | 136 ± 16 | 241 ± 32 | 142 ± 28 | 96 ± 16 | NS | <0.001 | <0.01 | <0.001 |
| HDL Cholesterol (mg/dL) | 142 ± 14 | 130 ± 14 | 256 ± 29 | 169 ± 15 | 203 ± 26 | NS | <0.001 | <0.001 | <0.05 |
| Non-HDL Cholesterol (mg/dL) | 10 ± 3 | 12 ± 3 | 15 ± 6 | 14 ± 2 | 10 ± 3 | NS | NS | NS | NS |
| NEFA (mM) | 3 ± 0.29 | 3.1 ± 0.4 | 5.9 ± 1 | 3.6 ± 0.7 | 4.8 ± 1 | NS | <0.001 | <0.001 | <0.05 |
| GTT-AUC (mg*min/dL X 103) | 3 ± 0.29 | 3.6 ± 0.46 | 6.1 ± 1 | 6.2 ± 1 | 5.9 ± 1.2 | NS | <0.001 | NS | NS |