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Planned dose escalation and MTD cohort expansion.
| Dose level | Patients | CQ (first cohort) HCQ (all subsequent patients) (mg/day) | Carboplatin (AUC) | Gemcitabine (mg/m2) |
|---|---|---|---|---|
| Day −7 to day 21 | Day 1 | Day 1 and 8 out of 21-day cycle | ||
| 1 | 3–6 | CQ 50 mg daily | 5 | 1,250-1,000 |
| 2 | 3–6 | HCQ 100 mg daily | 5 | 1,000 |
| 3 | 3–6 | HCQ | 5 | 1,000 |
| 4 | 3–6 | 200 | 5 | 1,000 |
| Expansion cohort | 10–12 | 100 | 5 | 1,000 |
