Table 3.
Univariate association of registered patient and disease characteristics with the pattern of treatment of stage IA cervical carcinoma. Emilia-Romagna Region, Italy (1995–2016).
| Characteristic | Number | Pattern of Treatment | p-Value * | |||
|---|---|---|---|---|---|---|
| Conservative without LND (n = 350) |
Conservative with LND (n = 12) |
Hysterectomy without LND (n = 317) |
Hysterectomy with LND (n = 197) |
|||
| Age (years) and screening experience | <0.001 | |||||
| <40 | 286 | 193 (67.5) | 3 (1.0) | 51 (17.8) | 39 (13.6) | |
| 40–64, SD | 292 | 89 (30.5) | 6 (2.1) | 122 (41.8) | 75 (25.7) | 0.378 † |
| 40–64, non-SD | 196 | 48 (24.5) | 2 (1.0) | 90 (45.9) | 56 (28.6) | |
| ≥65 | 102 | 20 (19.6) | 1 (1.0) | 54 (52.9) | 27 (26.5) | |
| Place of birth | 0.156 | |||||
| Low-emigration country | 775 | 309 (39.9) | 10 (1.3) | 289 (37.3) | 167 (21.5) | |
| High-emigration country | 101 | 41 (40.6) | 2 (2.0) | 28 (27.7) | 30 (29.7) | |
| Health care district | 0.001 | |||||
| North-western Emilia | 354 | 161 (45.5) | 8 (2.3) | 123 (34.7) | 62 (17.5) | |
| Central Emilia | 235 | 71 (30.2) | 2 (0.9) | 91 (38.7) | 71 (30.2) | |
| Romagna | 287 | 118 (41.1) | 2 (0.7) | 103 (35.9) | 64 (22.3) | |
| Time period of diagnosis | <0.001 | |||||
| 1995–1999 | 262 | 73 (27.9) | 4 (1.5) | 127 (48.5) | 58 (22.1) | |
| 2000–2004 | 243 | 101 (41.6) | 1 (0.4) | 96 (39.5) | 45 (18.5) | |
| 2005–2010 | 226 | 104 (46.0) | 2 (0.9) | 60 (26.5) | 60 (26.5) | |
| 2011–2016 | 145 | 72 (49.7) | 5 (3.4) | 34 (23.4) | 34 (23.4) | |
| Tumour type | 0.023 | |||||
| Squamous carcinoma | 738 | 292 (39.6) | 9 (1.2) | 283 (38.3) | 154 (20.9) | |
| Adenocarcinoma | 126 | 52 (41.3) | 3 (2.4) | 30 (23.8) | 41 (32.5) | |
| Other, unknown | 12 | 6 (50.0) | 0 (0.0) | 4 (33.3) | 2 (16.7) | |
| Tumour location | 0.066 | |||||
| Exocervical | 143 | 52 (36.4) | 6 (4.2) | 50 (35.0) | 35 (24.5) | |
| Endocervical | 345 | 145 (42.0) | 2 (0.6) | 121 (35.1) | 77 (22.3) | |
| Unknown | 388 | 153 (39.4) | 4 (1.0) | 146 (37.6) | 85 (21.9) | |
| Tumour grade | <0.001 | |||||
| 1 | 84 | 40 (47.6) | 1 (1.2) | 30 (35.7) | 13 (15.5) | |
| 2 | 93 | 18 (19.4) | 2 (2.2) | 30 (32.3) | 43 (46.2) | |
| 3–4 | 63 | 21 (33.3) | 0 (0.0) | 20 (31.7) | 22 (34.9) | |
| Unknown | 636 | 271 (42.6) | 9 (1.4) | 237 (37.3) | 119 (18.7) | |
| Tumour stage | <0.001 | |||||
| IA1 | 375 | 174 (46.4) | 4 (1.1) | 129 (34.4) | 68 (18.1) | |
| IA2 | 103 | 26 (25.3) | 4 (3.9) | 26 (25.2) | 47 (45.6) | |
| IA NOS | 398 | 150 (37.7) | 4 (1.0) | 162 (40.7) | 82 (20.6) | |
LND, lymph node dissection; NOS, not otherwise specified; SD, screen-detected. Numbers in parentheses are row percentages. * For the Pearson chi-square test. † Test for the difference between screen-detected and non-screen-detected patients aged 40–64 years.