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. 2022 May 3;11(9):1528. doi: 10.3390/cells11091528

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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LINC00152 controls the bioavailability of miR-143-3p. (A) Putative miRNA components of the LINC00152 ceRNA network showing binding sites for both LINC00152 and KLC2. (B,C) Reduced luciferase reporter activity due to binding of a miR-143a-3p mimic to LINC00152 respectively KLC2 in HuH7 cells. (D,E) Decreased KLC2 mRNA and protein levels following miR-143a-3p mimic transfection in HuH7 cells. (F) Transient miR-143a-3p overexpression lowered the cell viability of HuH7 compared to control cells. Data are presented as mean ± SD of at least 3 independent experiments. Student t-test in panel (F) and Welch’s t-test for (A–E): * p < 0.05, ** p < 0.01. Abbreviations: rel., relative.