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. 2022 May 3;11(9):1528. doi: 10.3390/cells11091528

Figure 6.

Figure 6

KLC2 and LINC00152 are co-expressed in HCC patients. (A) RNA hybridization signals of both LINC00152- and KLC2-specific RNA probes are more abundant in HCC cells compared to the surrounding non-tumorous liver (SL). Note, the co-expression of both transcripts. Dotted lines indicate the boundary between HCC and SL. Scale bar: 60 µM. (B) Semiquantitative scoring reveals upregulation of both LINC00152 and KLC2 transcripts in a human HCC cohort. (C,D) Upregulation of KLC2 and LINC00152 mRNA in human HCCs of the TCGA cohort. (E) Downregulation of miR-143a-3p expression in human liver tumors compared to normal tissues included in the TCGA dataset. (F) Kaplan-Meier curve showing shorter overall survival probability of HCC patients with higher KLC2 expression levels (TCGA cohort). Paired t-test in panel B and Wilcoxon test in panel (C–E) *** p < 0.001. Abbreviations: SL, surrounding normal liver; fc, fold change.