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. 2022 May 4;23(9):5115. doi: 10.3390/ijms23095115

Figure 11.

Figure 11

The effects of the peptides on ATP-induced Neuro-2a cell viability and activation of P2X7R. (a) Impact of the peptides on Neuro-2a cell viability in the presence of 4 mM ATP. The peptides were tested at concentrations of 0.01, 0.1, and 1.0 μM. Cells were incubated with peptides for 1 h at 37 °C, then for 48 h with ATP. (b) Effects of the peptides (0.01, 0.1, and 1.0 μM) on YO-PRO-1 uptake in Neuro-2a cells. ATP was used as a P2X7R agonist. A438079 (10 μM) was used as a standard inhibitor of P2X7R. The peptide effects were evaluated against the effects of ATP. The data are shown as means ± SE; *—p < 0.05 compared to the effect of ATP alone.