Figure 12.

Influence of HCIQ4c7 and HMIQ3c1 on ATP-induced calcium influx in Neuro-2a cells. (a) Representative time course of [Ca²⁺]_I increases induced by ATP (1 mM) alone or in the presence of the peptides or the P2X7R blocker A438079 (10 μM) in Neuro-2a cells, as measured with Fluo-8. (b) Effect of pre-incubation of Neuro-2a cells with the peptides (0.1, 1.0, and 10.0 μM) or A438079 (10 μM) on Ca²⁺ influx caused by ATP (1 mM). The data are shown as the means ± SE; **—p < 0.01, and ***—p < 0.001 compared to the effect of ATP alone.