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. 2022 Apr 29;15:828891. doi: 10.3389/fnmol.2022.828891

FIGURE 3.

FIGURE 3

Electrophysiological analysis showed E/I imbalance in TLE mice. (A) Neuronal response types of putative glutamatergic neurons to RA in dDG/CA3 of WT mice [Red, excited (Act.); blue, inhibited (In.); gray, no response (N.R.). n = 64 cells from 5 mice]. Venn diagram shows the distribution of approached RA-excited only, avoid RA-excited only or dual-excited putative glutamatergic neurons in dDG/CA3 of WT mice at RA. (B) Neuronal response types of putative glutamatergic neurons to RA in dDG/CA3 of TLE mice (Red, excited; blue, inhibited; gray, no response; n = 76 cells from 5 mice). Venn diagram shows the distribution of approached RA-excited only, avoid RA-excited only or dual-excited putative glutamatergic neurons in dDG/CA3 of TLE mice at RA. (C) Neuronal response types of putative GABAergic neurons to RA in dDG/CA3 of WT mice (Red, excited; blue, inhibited; gray, no response; n = 40 cells from 17 mice). Venn diagram shows the distribution of approached RA-excited only, avoid RA-excited only or dual-excited putative glutamatergic neurons in dDG/CA3 of WT mice at RA. (D) Neuronal response types of putative GABAergic neurons to RA in dDG/CA3 of TLE mice (Red, excited; blue, inhibited; gray, no response; n = 104 cells from 15 mice). Venn diagram shows the distribution of approached RA-excited only, avoid RA-excited only or dual-excited putative glutamatergic neurons in dDG/CA3 of TLE mice at RA. (E) Neuronal response types of putative GABAergic neurons to RA in dDG/CA3 of WT mice (Red, excited; blue, inhibited; gray, no response; n = 291 cells from mice). Venn diagram shows the distribution of approached RA-excited only, avoid RA-excited only or dual-excited putative glutamatergic neurons in dLS of WT mice at RA. (F) Neuronal response types of putative GABAergic neurons to RA in dDG/CA3 of TLE mice (Red, excited; blue, inhibited; gray, no response; n = 346 cells from mice). Venn diagram shows the distribution of approached RA-excited only, avoid RA-excited only or dual-excited putative glutamatergic neurons in dLS of TLE mice at RA.