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. 2022 Apr 29;15:828891. doi: 10.3389/fnmol.2022.828891

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Copyright © 2022 Cao, Sun, Huang, Sun, Wang, He, Liao, Lu, Lu and Zhong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kainic acid-induced TLE mice showed transcriptome alterations in the hippocampus and lateral septum. (A) Volcano plot of relative RNA expression in DG/CA3 from TLE mice as compared to WT mice. (B) Volcano plot of relative RNA expression in dLS from TLE mice as compared to WT mice [Genes in upper left and right quadrants are significantly differentially expressed. Red dots, up-regulation (dHPC, 65 genes; LS, 34 genes), blue dots, down-regulation (dHPC, 224 genes; LS, 11 genes). WT, n = 4 mice; TLE, n = 6 mice. p < 0.05].