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. 2022 May 6;14(9):2305. doi: 10.3390/cancers14092305

Figure 1.

Figure 1

OncomiR indices are increased in cerebrospinal fluid of CNS-involving lymphomas. OncomiR indices (logistic regression model) combining expression of oncogenic microRNAs (oncomiRs, miR-21/-19a/-20a/-92a/-155 as in Table 1) into single classifier in cerebrospinal fluid (CSF) of lymphoma patients with indicated B-NHL diagnoses. (A) Lymphoma patients with secondary CNS involvement (SCNSL), compared to systemic lymphoma patients and control patients (CTRL). (B) SCNSL lymphomas are subdivided into lymphoma with secondary CNS involvement presented at the time of diagnosis (SCNSL dg) and newly detected CNS relapses. (C) OncomiR indices in CSF of DLBCL stratified according to parenchymal, meningeal, and combined parenchymal and meningeal (P+mening) CNS involvement (all BL-SCNSL are from dg). qRT-PCR. The red line indicates the threshold for positive CNS lymphoma involvement. Log2 scale. Median ± interquartile range, * p < 0.05, ** p < 0.01, *** p < 0.001, Kruskal-Walliss. No star = non-significant.