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mAb2 bispecific molecules contain antigen binding Fc fragments (Fcabs), which can be derived from yeast Fcab libraries: (a) Model of a mAb2 antibody: Fab fragment in light teal, Fc in gray, and modified residues in the Fc-CH3 domain highlighted in blue (AB loop) and red (EF loop). The Figure was prepared using PyMOL version 2.5 (Schrödinger LLC.) based on PDB:1HZH; (b) Scheme of selection and pool expansion of CD59-reactive Fcabs (EU numbering scheme for antibody amino acids is used).
