Figure 1.

Summary of how the list of 533 BACE1-dependent proteins and 120 BACE1 potential substrates was obtained. Proteomics data from various studies acquired through datamining was filtered by fold change and p value and combined. This list of 533 BACE1-dependent proteins was then compared against a list of 934 bioinformatically predicted BACE1 substrates [37], to give a list of 120 BACE1 potential substrates which was the basis of further analysis [14,33,34,35,36].