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The 120 BACE1 substrates, identified from BACE1 experimental dependent proteins overlaid with BACE1 predicted substrates, were found to be associated with various functions including axon guidance and cell adhesion. (a) Venn diagram overlaying 533 experimental secreted BACE1 dependent proteins, and 934 bioinformatically predicted BACE1 substrates [37]. (b–d) Terms from various databases when the 120 BACE1 substrates where input into Enrichr, showing log of adjusted p-value.
