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Experimental validation of NCAM1, PTPRD, and DCC as BACE1 substrates. Western blots were performed on protein lysates from BACE1 knockout (KO) and wildtype (WT) brain endothelial cells (BECs) or hCMEC/D3 treated with M-3 or transfected with BACE1. Relative protein expression of full length NCAM1 (A,D,G), PTPRD (B,E,H), and DCC (C,F,I) after normalisation to beta actin. PTPRD and DCC gene expression (J,K) in hCMEC/D3. N = 3 per group, * denotes p < 0.05.
