Table 2.
The 25 BACE1 substrates differentially expressed in Alzheimer’s disease (AD). Identified from BACE1 experimental dependent proteins overlaid with BACE1 predicted substrate [37], subsequently compared against proteins differentially expressed in brain samples from individuals with AD and other non-AD diseases (epilepsy, stroke, traumatic brain injury, experimental autoimmune encephalitis). BACE1 substrates that are AD-specific are shaded grey. Validated and well-characterised substrates are shown in red. Details can be searched on GeneCards: https://www.genecards.org/ accessed on 6 May 2020.
| Protein Name | Gene Symbol |
|---|---|
| Activated Leukocyte Cell Adhesion Molecule | ALCAM |
| Amyloid Beta Precursor Like Protein 2 | APLP2 |
| VWFA and cache domain-containing protein 1 | CACHD1 |
| Cell Adhesion Molecule 1 | CADM1 |
| Contactin Associated Protein 2 | CNTNAP2 |
| Contactin Associated Protein Family Member 4 | CNTNAP4 |
| Cysteine Rich Transmembrane BMP Regulator 1 | CRIM1 |
| Netrin receptor DCC | DCC |
| Delta and Notch-like epidermal growth factor-related receptor | DNER |
| Ephrin type-A receptor 4 | EPHA4 |
| Low-density lipoprotein receptor | LDLR |
| LIF Receptor Subunit Alpha | LIFR |
| Lymphatic Vessel Endothelial Hyaluronan Receptor 1 | LYVE1 |
| Neurexin-3 | NRXN3 |
| Neurotrimin | NTM |
| Neurotrophic Receptor Tyrosine Kinase 2 | NTRK2 |
| Protocadherin-10 | PCDH10 |
| Plexin B1 | PLXNB1 |
| Protein Tyrosine Phosphatase Receptor Type D | PTPRD |
| Protein Tyrosine Phosphatase Receptor Type M | PTPRM |
| Roundabout Guidance Receptor 1 | ROBO1 |
| Roundabout Guidance Receptor 2 | ROBO2 |
| Syndecan 4 | SDC4 |
| Sidekick Cell Adhesion Molecule 1 | SDK1 |
| Sortilin Related Receptor 1 | SORL1 |