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. 2022 May 2;23(9):5041. doi: 10.3390/ijms23095041

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Olaparib downregulates and PDD00017273 upregulates the mRNA expression of osteogenic differentiation-related genes. MC3T3-E1 cells were treated with 1 µM olaparib, 1 µM PDD00017273, or DMSO for 0–28 days in differentiation medium. The mRNA expression levels of osteoblast differentiation-related genes were analyzed by qRT-PCR and normalized to the mRNA expression in DMSO-treated cells on day 7 after incubation in differentiation medium. (A) Ocn, Bsp, and Opn, as osteoblast differentiation markers. (B) Runx2, Osx, and Atf4, as transcription factors for osteoblast differentiation. (C) Parp1 and Parg. OLA, 1 µM olaparib; PDD, 1 µM PDD00017273. Data are shown as mean ± SE. * p < 0.05, ** p < 0.01 (Tukey’s test).