Table 1.
Halo of inhibition (mm) * of Candida and filamentous fungi by acylhydroquinones.
| Compounds | R | Candida albicans A8 | Candida glabrata 2001 | Candida krusei 118 | Aspergillus fumigatus 280 | Aspergillus fumigatus 2H | Aspergillus terreus | Acremonium kiliense | Rhizopus oryzae |
|---|---|---|---|---|---|---|---|---|---|
| 2–ABHQ | |||||||||
| 3 | C5H11 | 23 | 24 | 14 | 11 | 15 | 14 | - | 7 |
| 4 | C7H15 | 13 | 13 | 11 | 19 | 19 | 15 | 20 | 8 |
| 5 | Ph | 14 | 17 | 10 | <7 | <7 | <7 | <7 | <7 |
| 6 | CH = CHPh | 9 | - | - | - | - | - | - | - |
| 7 | 2-thienyl | 5 | 7 | 9 | - | - | 12 | 7 | - |
| 8 | 2-furyl | - | - | 8 | - | - | - | - | - |
| 2–ANHQ | |||||||||
| 9 | CH3 | 9 | 11 | 9 | - | - | - | - | - |
| 10 | C5H11 | - | - | - | - | - | - | - | - |
| 11 | C7H15 | - | - | - | - | - | - | - | - |
| 12 | Ph | 11 | 19 | 15 | - | 9 | - | - | 7 |
| 13 | CH = CHPh | 11 | - | 11 | - | <7 | - | - | - |
| 14 | 4-OH-3-MeOPh | 10 | 15 | 14 | - | - | - | - | - |
| 15 | 2-thienyl | 15 | 15 | 15 | - | 7 | - | - | - |
| 16 | 2-furyl | - | 10 | 11 | - | - | - | - | - |
(*) mm: millimeters. −(ndash): no zone of inhibition was detected. 2-ABHQ = 2-Acylbenzohydroquinone; 2-ANHQ = 2-Acylnaphthohydroquinone.