Table 2.
MIC values (μg/mL) of amphotericin B and the selected acylhydroquinones.
| Compounds | R | Candida albicans A8 | Candida glabrata 2001 | Candida krusei 118 | Aspergillus fumigatus 280 | Aspergillus fumigatus 2H | Aspergillus terreus | Acremonium kiliense | Rhizopus oryzae |
|---|---|---|---|---|---|---|---|---|---|
| 2–ABHQ | |||||||||
| 3 | C5H11 | 16 | 16 | 4 | 16 | 64 | 16 | 16 | 32 |
| 4 | C7H15 | 8 | 4 | 2 | 8 | 16 | 8 | 8 | 4 |
| 5 | Ph | >64 | >64 | >64 | NA | NA | NA | NA | NA |
| 2–ANHQ | |||||||||
| 12 | Ph | >64 | 32 | 4 | - | >64 | - | >64 | >64 |
| 14 | 4-OH-3-MeOPh | >64 | >64 | 64 | NA | NA | NA | NA | NA |
| 15 | 2-thienyl | >64 | 16 | 8 | >64 | 32 | - | 32 | 32 |
| Control | Amphotericin B | 0.5 | 0.5 | 1 | 1 | 0.5 | 1 | 2 | 1 |
NA: no applicable; 2-ABHQ = 2-Acylbenzohydroquinone; 2-ANHQ = 2-Acylnaphthohydroquinone.