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Summary of KIT mutations in AML.
| Exon | Description | Functional Impact |
|---|---|---|
| 8 | T417, Y418, D419 | Hyper-reactivity to stem cell factor |
| 10–11 | V530, V540, W557, V559, L576, ITD | Spontaneous dimer formation |
| 17 | D816, D820, N822, Y823, V825 | Auto activation |
Abbreviations: AML: acute myeloid leukemia.
