Table 3.
Frequency of KIT mutations in CBF-AML.
| Author, Year | Disease Status | Frequency of KIT Mutations | ||
|---|---|---|---|---|
| CBF Leukemia | RUNX1-RUNX1T1 | CBFβ-MYH11 | ||
| Qin 2014 | Newly diagnosed | 37% (128/351) | 39% (99/253) | 30% (29/98) |
| Allen 2013 | Newly diagnosed | 28% (100/354) | 23% (46/199) | 35% (54/155) |
| Kim 2013 | Newly diagnosed | 26% (32/121) | 27% (22/82) | 35% (54/155) |
| Ishikawa 2019 | Newly diagnosed | 34% (63/199) | 32% (42/132) | 31% (21/67) |
| HM-SCREEN01 | R/R or Unfit | 59% (10/17) | 67% (8/12) | 40% (2/5) |
Abbreviations: CBF: core-binding factor, R/R: relapse/refractory.