Table 4.

Summary of KIT mutations and chromosomal karyotypes.

		KIT Mutation
ID	Category	Description	SNV	VAF	Other Mutations	Chromosomal Karyotype
13	Unfit	D816V	2447A > T	0.372	FLT3, KRAS, CEBPA, TP53	Complex karyotype
50	Unfit	D816V	2447A > T	0.123	RAD21, SPEN	t(8;21)(q22;q22.1)
56	Unfit	D816F	2446_2447GA > TT	0.37	TP53, CDKN2A, CDKN2B	Complex karyotype
149	Unfit	D816V	2447A > T	0.344	ASXL1, DNMT3A, SETBP1, FANCD2, CASP8	46, XY, t(3;3)(p25:q13)
158	Unfit	T417_D419 > Y	1249_1255ACTTACG > T	0.078	FLT3, NRAS	inv(16)/t(16;16)
160	Unfit	D816V	2447A > T	0.146	CSF3R, JAK1	t(8;21)(q22;q22.1)
		N822K	2466T > G	0.018
10	R/R	D816V	2447A > T	0.234	None	t(8;21)(q22;q22.1)
39	R/R	D816V	2447A > T	0.252	RAD21	t(8;21)(q22;q22.1)
		D816Y	2446G > T	0.056
45	R/R	D816Y	2446G > T	0.923	CD36	t(8;21)(q22;q22.1)
76	R/R	D816V	2447A > T	0.932	NF1	t(8;21)(q22;q22.1)
94	R/R	D816V	2447A > T	0.459	RAD21, NPM1	Normal
111	R/R	D816V	2447A > T	0.338	SETD2	3q Abnormality
121	R/R	D816Y	2446G > T	0.021	CBL	inv(16)/t(16;16)
146	R/R	D816V	2447A > T	0.082	GATA2, HIST1H2BJ	t(8;21)(q22;q22.1)
175	R/R	N822K	2466T > G	0.461	GATA2, PHF6, ATM	t(8;21)(q22;q22.1)

Abbreviations: R/R: relapse/refractory, SNV: single-nucleotide variant, VAF: variant allele frequency.