Table 3.

Cold-induced symptoms during each trial

	30 min			90 min
Symptom	Before	After	+ 20 min	Before	After	+ 20 min
Nasal irritation	0.25 (0–1)	2 (0.25–2)**	0 (0–1)	0.25 (0–1)	2 (0.875–3)**	0.5 (0–1)
Nasal mucus	1 (0.375–2.25)	4 (3–5)***	1 (0.5–2)	1 (0.75–2)	5 (4–6.25)***	0.75 (0.375–2)
Cold face	0 (0–0)	3 (2–4.5)***	0 (0–0.625)*	0 (0–0)	3.5 (3–6)***	0.25 (0–1)*
Cold extremities	0 (0–0.6)	3 (0–4.5)**	0.5 (0–1)	0 (0–0.875)	3.5 (1.75–6.5)**†	1.25 (0–3)
Physical discomfort	0 (0–0.5)	2 (0–3)**	0 (0–0.5)	0 (0–0.5)	2.5 (0.5–4)**	0.5 (0–2)†
Shortness of breath	0 (0–0.5)	2 (1–2)**	0 (0–1)	0 (0.25–0.5)	2 (1–3)***	0.25 (0–0.5)
Warm in body	1.5 (0–3)	3 (0.75–4)	1 (0.5–3)	2 (0.5–3)	4 (2–5)**†	3 (1.25–3.5)†
Irritation in the chest	0 (0–0.5)	0 (0–2)	0.25 (0–1)	0 (0–1)	1.25 (0–2)**	0.5 (0–2)
Irritation in the mouth and throat	1 (0.375–2.25)	4 (3–5)	1 (0–2)	1 (0.75–2)	5 (4–6.25)**	1 (0–2.25)

Data are presented as median (IQR). Significant difference within trial, compared to baseline (*, p < 0.05, **, p < 0.01; ***, p < 0.001); ^†Significant difference between trials (p < 0.05)