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. 2022 Apr 29;12:864479. doi: 10.3389/fcimb.2022.864479

Table 1.

Summary of oral bacteria affecting cell migration.

Bacteria species Cell types Infection conditions Effect on cell migration Ref
P. gingivalis ATCC 33277 human immortalized oral epithelial cells (HIOECs) MOI=1, 24 h
repeatedly in 5, 10, 15, and 23 weeks
promote (Geng et al., 2017)
primary human oral epithelial cells (OECs) MOI=10 and 100, 120 h promote (Lee et al., 2017)
primary gingival keratinocytes MOI=10, 24 h inhibit (Bhattacharya et al., 2014)
Human telomerase immortalized gingival keratinocytes (TIGK) MOI=100,1 h, followed by 23 h in fresh medium promote (Fitzsimonds et al., 2021)
TIGK MOI=100, 24 h promote (Ohshima et al., 2019)
Human immortalized oral keratinocyte cell line OKF6/hTERT-1 MOI=100, 24 h promote (Hoppe et al., 2019)
human OSCC cell lines, UM-SCC-14A (floor of mouth) and HSC-3 (tongue) MOI=10,50,100,2 h promote (Kamarajan et al., 2020)
SAS and Ca9-22 cells MOI=1, 24 h promote (Inaba et al., 2014)
OSC-20 and SAS cells MOI=100,3 h promote (Ha et al., 2016)
Human esophageal cancer cell lines NE6-T, KYSE-30 and KYSE-150 MOI=10, 48 h promote (Liang et al., 2020; Qi et al., 2020)
secreted gingipains of
P. gingivalis ATCC33277
human embryonic microglia clone 3 (HMC3) cell line MOI=1,12 h promote (Nonaka and Nakanishi, 2020)
Outer membrane vesicles (OMVs) of P. gingivalis ATCC 33277 OSCC cell line (HSC-3) 6 h promote (Liu et al., 2021b)
Ltp1 of P. gingivalis ATCC 33277 TIGK MOI=100, 6 h promote (Liu et al., 2021a)
Heat-killed P. gingivalis ATCC 33277 OSCC cell line(H400) MOI=100, 8 d promote (Abdulkareem et al., 2018a)
P. gingivalis W83 human buccal epithelial cell line HO-1-N-1 MOI=10,100, 17 h inhibit (Laheij et al., 2013)
heat-killed P. gingivalis W83 human buccal epithelial cell line HO-1-N-1 MOI=100, 1000,17 h inhibit (Laheij et al., 2013)
conditioned medium from P. gingivalis W83 human buccal epithelial cell line HO-1-N-1 MOI=100,17 h inhibit (Laheij et al., 2013)
P. gingivalis strain 381 Ca9-22 OSCC cells MOI=100, 2 h promote (Ha et al., 2015)
F. nucleatum ATCC 25586 primary gingival keratinocytes MOI=10:1, 24 h inhibit (Bhattacharya et al., 2014)
human OSCC cell lines, UM-SCC-14A (floor of mouth) and HSC-3 (tongue) MOI=10,50,100,2 h promote (Kamarajan et al., 2020)
Colorectal cancer cell lines (HCT-116, LoVo) MOI=100, 12 h and 24 h promote (Chen et al., 2020; Xu et al., 2021a)
Heat-killed F. nucleatum ATCC 10953 OSCC cell line(H400) MOI=100, 8 d promote (Abdulkareem et al., 2018a)
OSCC cell line(HOC621 cells) MOI=10, 3 h promote (Shao et al., 2021)
Heat-killed F. nucleatum JCM8532 OSCC cell line(HOC621 cells) MOI=10, 3 h promote (Shao et al., 2021)
Live or heat-killed F. nucleatum JCM11024 OSCC cell line(HOC621 cells) MOI=10, 3 h promote (Shao et al., 2021)
Live or heat-killed F. nucleatum ATCC23726 OSCC cell line(HOC621 cells) MOI=10, 3 h promote (Shao et al., 2021)
T. denticola ATCC35405 human OSCC cell lines, UM-SCC-14A (floor of mouth) and HSC-3 (tongue) MOI=10,50,100,2 h promote (Kamarajan et al., 2020)
P. intermedia ATCC 25611
T. forsythia ATCC 43037
Conditioned medium from Streptococcus mitis LMG 14557 (MOI 100, 1000) and heat-killed Streptococcus mitis LMG 14557
Conditioned medium from Prevotella nigrescens ATCC 33563((MOI=100,1000) heat-killed Prevotella nigrescens ATCC 33563 (MOI 10, 100, 1000)
Heat-killed Prevotella intermedia ATCC 25611 (MOI 100, 1000)
Tannerella forsythia ATCC 43037 (MOI 50, 500)
human buccal epithelial cell line HO-1-N-1 MOI=10,100 or 1000, 17 h inhibit (Laheij et al., 2013)

Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model.