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. 2022 Apr 29;13:857400. doi: 10.3389/fimmu.2022.857400

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Copyright © 2022 Ghimire, Ederer, Meedt, Weber, Matos, Hiergeist, Zeman, Wolff, Edinger, Poeck, Herr, Gessner, Holler and Bülow

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL22 expression in dependence of GvHD and TRM. Patients were grouped according to absence or presence of TRM. IL22 gene expression normalized to 18s rRNA was measured. (A) Expression of IL22 in patients during histological GI-GvHD (no TRM: n = 82, TRM: n = 36). (B) Expression of IL22 in patients without and during clinical onset of GvHD (no TRM: n = 78, TRM: n = 27). Box plot diagrams depict median, upper, and lower quartiles and whiskers indicate minimal and maximal values. Negative values were set to 0.1. Statistical testing was performed using Mann-Whitney U test. ns, not significant.