Table 3.
Cox regression proportional hazard overall survival and recurrence-free survival: multivariable model for overall patients.
| Recurrence-Free Survival | Overall Survival | |||
|---|---|---|---|---|
| Variables | Hazard Ratio (95%CI) | p | Hazard Ratio (95%CI) | p |
| Propofol (ref. sevoflurane) | 1.04 (0.80, 1.34) | 0.80 | 1.12 (1.06, 1.17) | 0.91 |
| Age, year | 1.02 (1.01, 1.03) | 0.004 | 1.05 (1.03, 1.07) | 0.000 |
| ASA (ref. I) | 0.025 | 0.61 | ||
| II | 1.11 (0.82, 1.50) | 0.46 | 0.71 (0.41, 1.26) | 0.24 |
| III or IV | 1.76 (1.14,2.73) | 0.01 | 0.93 (0.42, 2.04) | 0.85 |
| Preoperative test | ||||
| Haemoglobin, mg/dL | 1.00 (0.98, 1.01) | 0.61 | 0.99 (0.95, 1.04) | 0.68 |
| Albumin | 0.83 (0.65, 1.07) | 0.15 | 0.14 (0.72, 0.47) | 0.14 |
| Creatinine, g/dL | ||||
| Neutrophil/Lymphocyte ratio | 1.07 (1.02, 1.11) | 0.006 | 1.12 (1.06, 1.17) | 0.000 |
| Neoadjuvant therapy | 1.70 (1.23, 2.34) | 0.001 | ||
| ECOG performance (ref. 0) | 0.73 | 0.09 | ||
| 1 | 0.91 (0.70, 1.18) | 0.48 | 1.27 (0.80, 2.01) | 0.31 |
| 2 | 1.12 (0.51, 2.49) | 0.78 | 1.29 (0.42, 4.00) | 0.66 |
| 3 | 2.30 (0.30, 17.86) | 0.43 | 22.84 (1.80, 290.72) | 0.02 |
| Operation (ref. laparotomy) | 0.005 | 0.009 | ||
| Laparoscopy | 1.17 (0.72, 1.88) | 0.53 | 0.51 (0.31, 0.84) | 0.009 |
| Robotic | 1.66 (1.22, 2.25) | 0.001 | 0.15 (0.24, 0.89) | 0.04 |
| T staging (ref. T0 or T1) | 0.000 | 0.000 | ||
| T2 | 1.24 (0.77, 2.00) | 0.37 | 0.99 (0.38, 2.55) | 0.98 |
| T3 | 2.88 (1.79, 4.65) | 0.000 | 2.32 (0.90, 5.98) | 0.08 |
| T4 | 88.36 (4.87, 14.35) | 0.000 | 8.48 (2.95, 24.40) | 0.000 |
| Tumor location (ref. Right) | 0.05 | |||
| Left | 0.60 (0.39, 0.92) | 0.019 | ||
| Rectum | 1.51 (0.19, 11.92) | 0.70 | ||
| Lymphatic invasion | 1.44 (1.12, 1.86) | 0.005 | 1.62 (1.01, 2.60) | 0.048 |
| Perineural invasion | 1.67 (1.27, 2.21) | 0.000 | 1.42 (0.84, 2.37) | 0.19 |
| Vascular invasion | 1.84 (1.38, 2.47) | 0.000 | 0.40 (0.20, 0.55) | 0.000 |
| Anaesthesia time, min | 1.00 (1.00, 1.00) | 0.16 | 1.00 (1.00, 1.00) | 0.18 |
| Transfusion | 0.93 (0.51, 1.71) | 0.81 | 1.20 (0.50, 2.89) | 0.69 |
| Postoperative treatment | 0.94 (0.67, 1.34) | 0.74 | 0.68 (0.37, 1.25) | 0.21 |
ASA, American Society of Anesthesiologists; BMI, body mass index; CAD, coronary artery disease; CCI, Charlson Comorbidity Index, CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; ECOG, Eastern Cooperative Oncology Group.