Table 6.
The association of NMR-measured ionized magnesium with the risk of developing type 2 diabetes at 5 year follow up visit in Insulin Resistance Atherosclerosis Study (IRAS) participants (n = 833). Insulin Resistance Atherosclerosis Study (IRAS) participants (n = 833).
| Total Participants (n = 833) | Wald χ2 | p-Value | Women (n = 473) |
Wald χ2 | p-Value | Men (n = 360) |
Wald χ2 | p-Value | |
|---|---|---|---|---|---|---|---|---|---|
| Events, n (%) |
131 (15.7) | - | - | 79 (16.7) | - | - | 52 (14.4) | - | - |
| Model 1 | 0.817 (0.677–0.986) | 4.4439 | 0.035 | 0.851 (0.666–1.087) | 1.6731 | 0.20 | 0.772 (0.576–1.036) | 2.9707 | 0.085 |
| Model 2 | 0.814 (0.669–0.991) | 4.1968 | 0.041 | 0.857 (0.662–1.110) | 1.3614 | 0.24 | 0.739 (0.543–1.007) | 3.6630 | 0.056 |
| Model 3 | 0.808 (0.664–0.985) | 4.4657 | 0.035 | 0.845 (0.651–1.097) | 1.5988 | 0.21 | 0.739 (0.542–1.006) | 3.6832 | 0.055 |
| Model 4 | 0.802 (0.655–0.983) | 4.5351 | 0.033 | 0.835 (0.637–1.093) | 1.7252 | 0.19 | 0.734 (0.536–1.005) | 3.7231 | 0.054 |
| Model 5 | 0.881 (0.719–1.080) | 1.4908 | 0.22 | 1.005 (0.760–1.329) | 0.0010 | 0.97 | 0.745 (0.545–1.018) | 3.4160 | 0.065 |
Events = type 2 diabetes at 5 year follow-up visit. Data are reported as odds ratio (95% confidence intervals) per 1 SD increment in plasma magnesium. Abbreviations: BMI, body mass index; FFA, free fatty acids; HOMA-IR, homeostatic model assessment for insulin resistance; LP-IR, Lipoprotein Insulin Resistance Index. Model 1: Adjusted for age, sex, race. Model 2: Model 1 and BMI, fasting insulin, and FFA. Model 3: Model 2 and GlycA. Model 4: Model 3 and HOMA-IR. Model 5: Model 3 and LP-IR.