Table 1.

Inhibition (%) values of compounds 3a–e, 4 and 5.

Compounds	R1	R	n	I (%) a
3a	H	H	1	31.7 ± 0.9
5	H	CH3	1	27.3 ± 2.6
3b	H	H	2	24.3 ± 3.5
3c	H	H	3	66.7 ± 5.5
3d	H	H	4	47.0 ± 5.7
3e	H	H	5	62.0 ± 6.0 (4)
4	COOH	H	1	97.0 ± 1.5

^a The compounds are tested in triplicate (unless indicated otherwise in brackets) using the voltage clamp technique on Xenopus Laevis oocytes expressing Panx-1 channels (at a concentration of 50 µM).