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. 2022 Apr 27;23(9):4827. doi: 10.3390/ijms23094827

Table 2.

Inhibition (%) values of compounds 7a–g, 8, 9 and 13.

graphic file with name ijms-23-04827-i002.jpg
Compounds R1 I (%) a
8 H 15.3 ± 4.9
7a SO2N(CH2CH3)2 54.0 ± 2.3
7b SO2N(CH2CH2CH3)2 34.3 ± 5.2
7c SO2N(CH2CH2CH2CH3)2 67.8 ± 2.2 (5)
9
Sodium salt of 7c		 SO2N(CH2CH2CH2CH3)2 65.3 ± 3.9
7d SO2N(CH2Ph)2 75.2 ± 5.90 (4)
7e SO2N(CH2CH2Ph)2 58.3 ± 7.5
7f SO2N(CH2CH2Ph)(CH2Ph) 61.3 ± 4.3
7g SO2NH(CH2CH2Ph) 47.3 ± 6.5 (4)
13 - 93.7 ± 2.3

a The compounds are tested in triplicate (unless indicated otherwise in brackets) using the voltage clamp technique on Xenopus Laevis oocytes expressing Panx-1 channels (at a concentration of 50 µM).