Table 3.

Inhibition (%) values of compounds 17, 18a–c, 19a–c, 23, 24 and 28–30.

Compound	R	R1	R2	I (%) a
17	H	H	H	0
18a	CH2CH3	H	H	0
18b	CH2CH2CH3	H	H	4.0 ± 2.3
18c	CH2CH2CH2CH3	H	H	10.3 ± 4.9
19a	CH2CH3	CH2CH3	H	14.3 ± 7.4
19b	CH2CH2CH3	CH2CH2CH3	H	21 ± 7.8
19c	CH2CH2CH3	CH2CH2CH3	CH2CH2CH3	28.0 ± 6.9
24	CH2-Ph	CH2-Ph	H	42.7 ± 2.4 (4)
23	CH2-Ph	H	H	16.3 ± 6.4
29	CH2CH2-Ph	H	CH2CH2-Ph	25.3 ± 0.9
28	CH2CH2-Ph	H	H	22.7 ± 5.5
30	CH2CH2-Ph	CH2-Ph	H	30.0 ± 7.2

^a The compounds are tested in triplicate (unless indicated otherwise in brackets) using the Voltage Clamp technique on Xenopus Laevis oocytes expressing Panx-1 channels (at a concentration of 50 µM).