Table 1.
Modulation of expression of genes involved in antigen processing and presentation (APP) MHC class I and II pathways and autophagy during infection of teleost fish species with viral pathogens.
| Virus 1 | Host Species | MHC I 2 APP | MHC II 2 APP | Autophagy 2 | Organ or Cell | Reference |
|---|---|---|---|---|---|---|
| VHSV | Lateolabrax japonicus | n.d. | − | n.d. | Brain cell line. | [105] |
| Sander vitreus | + | n.d. | n.d. | Skin fibroblast cell line. | [106] | |
| Oncorhynchus mykiss | + | n.d. | n.d. | Skin fibroblast cell line. | [107] | |
| + | + | + | Red blood cells and head-kidney. | [108,109] | ||
| n.d. | + | n.d. | Blood and spleen B cells. | [84] | ||
| Scophthalmus maximus | n.d. | n.d. | + | Red blood cells. | [73] | |
| Paralichthys olivaceus | n.d. | n.d. | + | Kidney and spleen. | [110] | |
| NNV |
Epinephelus coioides | + | n.d. | n.d. | Liver and spleen. | [47] |
| Sparus aurata | + | − | −/+ | Larvae. | [111] | |
| CSV | Oncorhynchus mykiss | + | n.d. | n.d. | Monocyte/macrophage cell line. | [44] |
| GCRV | Ctenopharyngodon idella | n.d. | n.d. | + | Kidney cell line. | [112] |
| SGIV | Epinephelus coioides | + | n.d. | n.d. | Liver and spleen. | [47] |
| IHNV | Oncorhynchus mykiss | + | − | n.d. | Spleen, intestines and head-kidney. | [113] |
| RBIV | Cynoglossus semilaevis | n.d. | + | n.d. | Kidney and spleen. | [61] |
| SAV3 | Salmo salar | + | n.d. | n.d. | Pancreas, heart, spleen, head-kidney, liver and gills. | [114] |
| ISKNV | Paralichthys olivaceus | + | n.d. | n.d. | Head-kidney, spleen and liver. | [115] |
1 Viral pathogens: Chum Salmon Reovirus (CSV), Grass carp reovirus (GCRV), Infectious hematopoietic necrosis virus (IHNV), Infectious spleen and kidney necrosis virus (ISKNV), Nervous Necrosis Virus (NNV), rock bream iridovirus (RBIV), RNA virus salmonid alpha virus 3 (SAV3), Singapore grouper iridovirus (SGIV), Viral Hemorrhagic Septicemia Virus (VHSV); 2 Expression of genes related to APP MHC class I pathways, APP MHC class II pathways or autophagy were (+) upregulated, (−) downregulated or (n.d.) not determined.